According to our multi-variate analysis, age, diabetes, and unilateral neck radiation may be related factors, although given the sample size and degrees of freedom in the model, p -values for all factors should be considered borderline significant, and interpreted with caution.
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Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer.
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Higher V 40Gy ( p = 0.047, OR = 1.06 {95% CI 1.00–1.12}), and younger age (mean age 56.6 vs 59.7, p = 0.060, OR = 0.96 {95% CI 0.92–1.00}) were associated with elevated risk of LS, with borderline significance.
Other authors postulate that anterior-posterior dose gradients may be significant because of spinothalamic tract damage [ 31 ].