marginally non-significantP = 0.055
In contrast, no significant heterogeneity ( I 2 = 22.3%; Cochran Q -test: P = 0.174) was found for OS, and the improvement in OS was minimal and marginally non-significant (HR = 0.93, 95% CI = 0.87 to 1.00; P = 0.055), as compared with controls.