Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet's induced membrane in rats.

In contrast, there is a decreasing trend of mean vessel density in both two groups (Fig. 2c , subcutaneous site, 2 weeks: 16.25 ± 3.28, 4 weeks: 12.37 ± 2.28 6 weeks: 5.27 ± 2.24; femoral defect site, 2 weeks: 46.30 ± 10.86, 4 weeks: 34.72 ± 7.82, 6 weeks: 24.83 ± 6.93).

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