Barely Significant
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Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide <i>in vitro</i> and in a mouse model.

Oncotarget · 2018 · PMC5940368 · PMID 29765554

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highly significantno p-value reported
In addition, a highly significant drop in tumor volume was observed at day 10 with unmodified PLGA-PEG nanoparticles containing antagomiRs, when compared with cRGD-targeted PLGA-PEG nanoparticles.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.