Impact of early changes in serum biomarkers following androgen deprivation therapy on clinical outcomes in metastatic hormone-sensitive prostate cancer.

To avoid the collinearity effect on the OS, Model II was built where a log-transformed baseline PSAlevel was removed from Model I that demonstrated that the p -values for a log-transformed PSA change, Hb level at 12 weeks, and ALP level at 12 weeks became closer to significance levels (Hb level was almost significant, but did not reach the significance level).

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