Barely Significant
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Changes in energy metabolism, and levels of stress-related hormones and electrolytes in horses after intravenous administration of romifidine and the peripheral α-2 adrenoceptor antagonist vatinoxan.

Acta Vet Scand · 2018 · PMC5944056 · PMID 29743097

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an increasing trendno p-value reported
Serum cortisol concentrations increased from baseline after all treatments, but no significant differences emerged between treatments (Table 2 ). Base excess showed an increasing trend after all treatments and there was a significant difference between baseline and T60 after ROM and V, but no significant differences were detected between the treatments.

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