Acylcarnitine Profiles in Plasma and Tissues of Hyperglycemic NZO Mice Correlate with Metabolite Changes of Human Diabetes.

J Diabetes Res · 2018 · PMC5944288 · PMID 29854816

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For cluster 3, especially high amounts of odd-numbered fatty acid-derived ACs like heptanoyl-carnitine (C7) and pentanoyl-carnitine (C5) as well as BCAA-derived ACs like 2-methylbutyryl-carnitine (2-M-C4) and isovaleryl-carnitine (3-M-C4) showed highly significant results while serine, glycine, alpha-aminoadipic acid (AADP), pentadecenoyl-carnitine (C15), and cystine (Cys-Cys) showed negative associations with cluster 3.

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