Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People.

The CYP2D6 gene was significantly associated with plasma concentrations of endoxifen ( P = 0.0008) and suggestive of significance for 4‐OH‐Tam ( P = 0.0074); individuals with higher activity scores had increased circulating endoxifen (Figure 2 a) and 4‐OH‐Tam (Figure 2 b) levels.

also in 66 other papers

11 The CYP2D6 diplotypes were highly significant predictors of tamoxifen metabolism in our study.

also in 132,142 other papers