Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.

Nat Biotechnol · 2018 · PMC5951394 · PMID 29227469

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highly significantno p-value reported

Notably, we find a highly significant enrichment for Alzheimer’s Disease (AD) risk variants in Mic (Z score = 5.41, Table S8 ), which is in line with the significant microglia signatures found activated in the late-onset AD cortex 52 and for AD-risk variants showing higher expression in microglia 53 .

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