A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

PLoS Pathog · 2018 · PMC5951583 · PMID 29718991

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closest p · 0.0× alpha

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The sentences

highly significantp < 0.0001actually significant

Highly significant (p < 0.0001) and close (Spearman r = -0.91) correlation between binding affinities determined by SPR and the mol% binding determined in the pull-down assays was observed for the interactions of both wild-type (closed symbols) and ΔH C loop-mutant (open symbols) H C B (triangles), H C DC (squares), and H C G (circles).

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