Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation.

PLoS Pathog · 2018 · PMC5951585 · PMID 29718999

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a positive trendno p-value reported

Although the effects of GE on PGT151 and PGT121 were relatively modest, there was also a positive trend.

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highly significantno p-value reported

Strain-specific effects Contrasting with the largely consistent and, in some cases, highly significant ( S1 Table ) patterns above, the most sensitive GE variant for some bnAbs differed between strains.

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