Highly significant downregulation of metabolic activity was found in both cell types (NIH 3T3: 9.44% ± 0.93; SH-SY5Y: 7.10% ± 0.51) following administration of 8.2 μg/ml Pt-Diss ( Fig 8 ).
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Platinum corrosion products from electrode contacts of human cochlear implants induce cell death in cell culture models.
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