The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis.

When capsule was taken into account, the difference in size became highly significant ( Fig 1E ; p<0.0001), suggesting that capsule size increases with base ploidy.

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Although CD11b + MHC-II hi cells (gate I) were present in both groups, mice infected with H99 displayed an increasing trend of this subset, while Zc1-infected mice had a significant increase in CD11b + MHCII lo cells (p = 0.0079, gate II) ( Fig 8C ).

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