<i>EIF2B2</i> mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.

First, fibroblasts derived from VWMD patients with EIF2B4 and EIF2B5 mutations on average displayed an almost significant ( P = 0.0500005, Student's t -test) ∼50% reduction in translation activity compared to ∼40% suppression of translation in control cells ( Kantor et al. 2005 ).

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