Barely Significant
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Protein-mediated loops in supercoiled DNA create large topological domains.

Nucleic Acids Res · 2018 · PMC5961096 · PMID 29538766

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might be significantno p-value reported
There might be significant advantages to topologically entangling more DNA than just the segment between the binding sites of a loop-mediating protein.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.