Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy.

Ann Intensive Care · 2018 · PMC5964054 · PMID 29789983

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Its prognostic impact might be significant, because it may lead to a reduction in the cumulative fluid balance, which by itself is clearly associated with poor prognosis (Fig. 4 ).

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