Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.

1b and 2g ); and the total cholesterol (TCh) and low-density lipoproteins-cholesterol (LDL-c) also showed a decreasing trend (Fig. 2h, i ).

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In addition, echocardiography showed an increasing trend in the left ventricular wall and myocardial contractility as evidenced by a greater ejection fraction and fractional shortening in the hyperinsulinemic monkeys at 40 months of follow-up studies (Fig. 2k, l ).

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