Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice.

4(b )). Effects of age and polyphenol-rich extract from grape and blueberry-enriched diet on hippocampal neurogenesis A two-way ANOVA on the number of DCX-IR cells revealed a highly significant age effect ( F (1,34) = 340·491; P < 0·0001), but no diet effect ( F (1,34) = 1·167; P = 0·2876) or age × diet interaction ( F (1,34) = 0·760; P = 0·3896), indicating that, irrespective of diet, aged mice have fewer newly generated immature neurons than adult mice ( Fig. 5(a )).

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