Barely Significant
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Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy.

Brain · 2018 · PMC5972596 · PMID 29718187

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a decreasing trendno p-value reported
Additionally, also in Patient 1, a decreasing trend of complex IV activity in muscle tissue, COX-negative fibres, and slightly decreased amount of complex IV in fibroblasts were observed.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.