Barely Significant
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Burden of vision loss in the Eastern Mediterranean region, 1990-2015: findings from the Global Burden of Disease 2015 study.

Int J Public Health · 2018 · PMC5973987 · PMID 28776250

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an increasing trendno p-value reported
An increasing trend was observed in age-standardized prevalence and rate of YLDs due to macular degeneration in both sexes.

also in 63,971 other papers

a decreasing trendno p-value reported
However, a decreasing trend in age-standardized prevalence and YLDs rate due to refraction and accommodation disorders was observed in this region.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.