Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction.

Several compounds such as 6 , 15 , and 18 (10–20 mg/kg; s.c.; b.i.d.) showed highly significant inhibitory activity ( p < 0.0001) and at a level approaching that of the MR-1 anti-CD154 antibody used as positive control ( Figure 6 ). 3.

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