Integrated Population Pharmacokinetic Analysis of Rivaroxaban Across Multiple Patient Populations.

2 In agreement with findings from previous indication‐specific rivaroxaban population PK models, 19 , 20 , 21 , 23 and as expected for a Biopharmaceutics Classification System class 2 substance, dose had a highly significant influence on F 2 ; this dependence was captured as a nonlinear function.

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The prediction‐corrected visual predictive checks also indicated a slight trend toward underestimation of C max .

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