Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications.

The metabolites of this excess selenium metabolism have been demonstrated to be pro-oxidative and result in increased levels of damaging reactive oxygen species (ROS) [ 155 ] Recent studies have shown that depression is associated with increased levels of oxidative stress biomarkers, strengthening the hypothesis that oxidative stress and inflammation may be significant factors in the pathogenesis of depression [ 149 ].

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