Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.

There was a slight trend, though not statistically different, in the decline of skeletal muscle mass index in elderly (10.9 kg/m 2 in pre-frail vs 12.1 kg/m 2 in active elderly, p = 0.21), highlighting, at least in these populations, that differences in muscle performance were not strictly linked to muscle mass, but were driven through other changes in the muscle biology.

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