Barely Significant
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The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness.

Sci Rep · 2018 · PMC5986773 · PMID 29867203

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The sentences

highly significantp < 0.00013actually significant
In the second stage, SNPs/loci that passed a significant threshold (p < 0.05) were further pruned down with bonferroni correction and only those SNPs that were highly significant (p < 0.00013, Supplementary Table 3 ), and belonged in particular, to the extracellular matrix (ECM) i.e., Aggrecan and Fibulin-1 genes were selected for genotyping, as these genes were up-regulated and associated with aPWV in the gene profiling work.

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