Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity.

Viral load portrayed a dichotomy by showing a highly significant, negative effect on IgG1 p17, IgG1 p24, and IgG3 gp41ΔMPER responses, contrasted by a positive association with IgG1 gp41ΔMPER and IgG2 gp120 responses, in particular the IgG2 BG505 trimer and BG505 gp140 reactivity ( Fig. 2 A and Fig. 3, A and B ).

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