Zbtb7a target promoters displayed highly significant enrichments for multiple GO terms ( Fig 2G ), prominently including processes linked to cell proliferation and apoptosis, gene regulation, and signal transduction (including inflammatory and innate immune responses, which encompass many of the NFκB target promoters, as well as several specific developmental signalling pathways [ S2M Fig ]).
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Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.
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