Physical Exercise Modulates L-DOPA-Regulated Molecular Pathways in the MPTP Mouse Model of Parkinson's Disease.

Of the tested parameters in the open field (total walking distance, total movement time, mean velocity, and mean angular velocity), the mean angular velocity was increased ( p < 0.001), and the total movement time showed a decreasing trend ( p = 0.051) for all treatment groups over time during the exercise regimen (i.e., main effect of “week”).

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The top regulators—and to a lesser extent also the canonical pathways and biofunctions—regulated by physical exercise in the cognition-associated brain areas of MPTP-treated mice, showed highly significant predicted directions of effect, whereas these effects were less prominent in the motor-related areas.

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