ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1.

Simultaneously, a difference was already apparent at 1–2 weeks in the ADM scaffold-treated mice compared with the saline-treated mice, with either Relm α or Arg1 peaking with a highly significant increase ( Relm α: an ~4-fold increase compared with the saline-treated mice at 2 weeks and an ~2-fold increase at 3 and 4 weeks, Figure 2I ; Arg1 : an ~2-fold increase compared with the saline-treated mice at 2 weeks and an ~1.5-fold increase at 3 and 4 weeks, Figure 2J ).

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