Ubiquitous Flame-Retardant Toxicants Impair Spermatogenesis in a Human Stem Cell Model.

iScience · 2018 · PMC5994764 · PMID 29901031

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an increasing trendno p-value reported

qRT-PCR results from the amplification of PIWIL2 (HILI) transcripts in our in vitro model showed an increasing trend for 100 μM TBBPA messenger RNA (mRNA) steady-state levels compared with control, with a roughly 80% increase that was not statistically significant ( Figure S3 A).

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a decreasing trendno p-value reported

Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) results from the amplification of ZBTB16 (PLZF) transcripts in our in vitro model show a decreasing trend at 100 μM HBCDD and TBBPA, with ZBTB16 mRNA steady-state levels at 30% and 45% of DMSO-only negative control levels, respectively, which correlates with our staining data ( Figure S2 A).

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