a trend towards significancep = 0.064
In addition, a small reduction in MFN1 expression with a trend towards significance compared to sham was observed in CKD lysates (9.8±0.3 versus 11.6±0.6; p = 0.064).
In addition, a small reduction in MFN1 expression with a trend towards significance compared to sham was observed in CKD lysates (9.8±0.3 versus 11.6±0.6; p = 0.064).
Study limitations Even though our prolong CKD model resulted in increased myocardial fibrosis and highly significant mitochondrial dysfunction, overt systolic heart failure was not documented.