Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

According to a likelihood ratio test, deterioration of the likelihood becomes highly significant ( p < 0.001) when the penalty strength passes the threshold of λ = 10, corresponding to 11 non-zero effects and a difference of 34 in terms of twice the negative log-likelihood.

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