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Anemia and mortality in patients with nondialysis-dependent chronic kidney disease.

BMC Nephrol · 2018 · PMC5996482 · PMID 29890958

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an increasing trendno p-value reported
Thus, our findings suggest that there is an increasing trend in current ESA use practice in more careful consideration when and in whom to start ESA (e.g. lower dosage, later introduction of ESAs in non-dialysis CKD population).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.