Indeed, the enrichment of variants revealed in SEC24B , based on 3/47 variants identified in the patients vs 1/652 in the controls, only indicates a statistical trend to be confirmed in studied of larger patient cohorts; variant enrichment in the FMRP gene set might reflect the higher number of genes making up this gene group as compared to the other gene sets investigated.
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Whole-exome sequencing to disentangle the complex genetics of hippocampal sclerosis-temporal lobe epilepsy.
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