Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients.

Hum Mol Genet · 2018 · PMC6005141 · PMID 29701772

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highly significantno p-value reported

However, highly significant alterations of other Ca 2+ signaling-related genes were found ( Fig. 6A ), including almost complete down-regulation of ATP2A1 (SR Ca 2+ -ATPase 1, SERCA1), the SERCA isoform specific for fast fibres ( 21 ), most likely reflecting type 1 (slow) fibre predominance ( 11 ).

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