Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice.

However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig. 5 ), resulting in a more youthful metabolomic signature in heart.

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