Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata.

Front Immunol · 2018 · PMC6008552 · PMID 29951053

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borderline significantno p-value reported

Blocking Mφ with anti-CD11b, NK with anti-CD314, and B cells with anti-sIgM in SC from naïve and AA mice showed borderline significant MDSC-Exo uptake inhibition, which was alike in naïve and AA LNC (data not shown).

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highly significantno p-value reported

In mice with AA totalis, the impact of MDSC-Exo application became significant after 6 weeks of treatment and was highly significant after 10 and 16 weeks, i.e., was maintained and even slightly improved 6 weeks after treatment termination (Figure 8 A).

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