Replacement of phenyl ( 4a ) by a 2-pyridyl group ( 10a ) or by a morpholinyl group ( 12a ) leads to a reduction of the inhibitory activity, which is highly significant for 12a (42.5 μΜ).
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Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX.
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