The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study.

Pulm Circ · 2018 · PMC6018906 · PMID 29251556

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may be significantno p-value reported

showing that a 1% reduction of LV pGLS in patients with heart failure with reduced EF was associated with increased mortality: hazard ratio = 1.15 (95% confidence interval [CI] = 1.04–1.27, P = 0.008), 36 a 0.9% improvement of LV pGLS in patients with SSc-PAH may be significant in terms of improving survival.

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