Deleting Death and Dialysis: Conservative Care of Cardio-Vascular Risk and Kidney Function Loss in Chronic Kidney Disease (CKD).

In addition, in an RCT, a borderline significant improvement of arterial calcification has been described in hemodialysis patients receiving magnesium supplementation [ 415 ].

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In a short-term study, allopurinol was shown to decrease blood pressure in young adolescents with newly diagnosed essential hypertension [ 528 ], but according to a recent Cochrane systematic review including more than 20 studies, results were overall negative (apart from borderline significance for clinic systolic blood pressure but no effect on 24 h blood pressure), with low quality studies and small therapeutic effects [ 529 ].

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