There was a decreasing trend in both SIRT1 and PPAR-α expression levels in the IDH2 FRU mice compared to the other groups, which is also in agreement with phenotypes (i.e., Figure 1 E).
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IDH2 Deficiency Aggravates Fructose-Induced NAFLD by Modulating Hepatic Fatty Acid Metabolism and Activating Inflammatory Signaling in Female Mice.
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