The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.

Although a slight trend toward a reduced LK compartment was observed ( Figure 4C ), no significant alterations were noted with respect to CD34+ CD16/32- CMPs (common myeloid progenitors), CD34+ CD16/32+ GMPs (granulocyte-monocyte progenitors) and CD34- CD16/32- MEPs (megakaryocyte-erythroid progenitors) ( Figure 4D ).

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