Osteoglycin, a novel coordinator of bone and glucose homeostasis.

Consistent with the disrupted insulin signaling and elevated circulating blood sugar seen in Ogn −/− mice, serum osteoglycin displayed a highly significant negative relationship with both fasting glucose (R 2 = 0.24, p < 0.01) and insulin (R 2 = 0.42, p < 0.001) levels in these mice ( Figure 7 C–D).

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