Long-Term Follow-Up of Acute Hepatitis B: New Insights in Its Natural History and Implications for Antiviral Treatment.

In addition, in 28 patients with an increasing trend in serum bilirubin (hence, closer to the beginning of the infection) the peak alteration of biochemical parameters correlated with the time to HBsAg clearance (AST R 2 = 0.318, p = 0.0082, ALT R 2 = 0.145, p = 0.0263; total bilirubin R 2 = 0.222, p = 0.011, Spearman correlation). 3.3.

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The differences between RR and SR patients is highly significant, and this parameter can be used as a robust predictive factor for clearing or not clearing HBsAg within six months (ROC curve, Figure 3 C, AUC 94%).

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