Dynamic bimodal changes in CpG and non-CpG methylation genome-wide upon CGGBP1 loss-of-function.

Indeed by comparing the differences in A+T to C+G shift, we found that the unmapped reads of CGGBP1-depleted samples had a small but highly significant 1.88% higher GC content (in CpG, CHG and CHH contexts all combined) than that of the control sample (Additional file 1 : Table S2) which was 0.09% at mapped reads (Additional file 1 : Table S2).

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