Barely Significant
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Does Estrogen Contribute to the Esophageal Barrier Function in Women?

Gut Liver · 2018 · PMC6027837 · PMID 29945422

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a decreasing trendno p-value reported
1 However, a very recent study from Japan indicated that the incidence of EAC has started to increase in Japan, 2 due at least in part to a decreasing trend in the Helicobacter pylori infection rate in the general Japanese population, which is lagging 50 years behind Western countries.

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