The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.

Significant differences are indicated using the standard Michelin Guide scale ( P < 0.05, significant; P < 0.01, highly significant; P < 0.001, extremely significant).

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Third, the comparison of the gene expression profiles of cells expressing the SLC25A1-shRNA or treated with CTPI-2, demonstrated clearly that approximately 80% of genes detected with CTPI-2 treatment were also found in SLC25A1-shRNA-expressing cells, with a highly significant overlap p -value (Fig. 3e ).

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