A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice.

Genome Biol · 2018 · PMC6031188 · PMID 29973285

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highly significantno p-value reported

This observation is also highly significant because it encourages the use of Cas9 and Cpf1 in certain breeding applications that may require expression of RGNs across several generations.

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