Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus.

Int J Mol Sci · 2018 · PMC6032060 · PMID 29867029

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While both mutants displayed properties typical of wild-type Cx43 (Cx43WT), they also showed unexpected properties that challenge current models of channel function and may be significant for the cardiac phenotypes of the (S3A, S3E) transgenic mice, as well as for the pathophysiology of cardiac ischemia and arrhythmogenesis. 2.

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