tendency toward significanceP = 0.06
As shown in Supplementary Figure 5 (available on the Arthritis Care & Research web site at http://onlinelibrary.wiley.com/doi/10.1002/acr.23497/abstract ), several PROs were more severe in ACPA‐positive RA patients during 4 years of followup; statistical significance was reached for general well‐being ( P = 0.020, β = 0.10) and a tendency toward significance for patient‐reported disease activity ( P = 0.06, β = 0.05).